Detection and Clinical Significance of the Cytokines in the Serum of Patients with Hepatic Cirrhosis

Objective:To explore the serum levels of cytokines of patients with posthepatitil cirrhosis(HPC) and the relationship between the cytokines and liver function.Method:Using ELISA technique to measure the serum levels of IL-6、IL-8、TNF-a in 58 patients with posthepatitic cirrhosis(PHC) and 35 healthy peoples.The patients with posthepatitic cirrhosis(PHC) were classified by A、B、C groups according to the standard of child-pugh.Result:The serum levels of IL-6、IL-8 and TNF-α of patients with PHC were significantly higher than those in healthy control group(P0.01).The serum levels of IL-6、IL-8 and TNF-α of Child-Pugh A、B、C groups were significantly higher than those in healthy groups.Conclusion:With the increase of the serum levels of IL-6、IL-8 and TNF-α,liver damage was aggravated,which indicated that there is an impediment in immune function and it is closely related to liver function.So it is of clinically value to adopt the serum levels of IL-6、IL-8 and TNF-α as an indicator to determine the degree to liver damage.