Advance in Research of Endostatin and its Antitumor Application

Endostatin is a kind of angiogenesis inhibitor,specific effecting in the new microvascular endothelial cells. The level of endostatin and the angiogenesis of tumor have a close correlation. In vivo and in vitro studies indicated that endostatin has some advantages such as least toxic and without side effects,hard to become drug resistant and easy to achieve an effective drug concentration. In this review we summarized the characteristics of endostatin,its mechanism and applied to antitumor.