Comparative Analysis on the Therapeutic Effect of Carvedilol and Metoprolol in the Treatment of Hypertension and Their Effect on Glucose and Lipid Metabolism

Objective To investigate the clinical curative effect of carvedilol and metoprolol in the treatment of hypertension and their effect on blood lipid and glucose metabolism.Methods 78 patients with stage Ⅰ and stage Ⅱ primary hypertension admitted to our hospital from March 2010 to November 2011 were randomly divided into carvedilol group(study group) and metoprolol group(control group).The blood pressure control,Glu,blood lipid,INS and ISI before and after treatment were observed and compared between the two groups.Results The efficacy of the two groups showed statistically significant difference(u=4.336,P=0.173).The systolic and diastolic blood pressure of the two groups both significantly decreased after treatment(P0.05).The Glu,INS,ISI,TG,TC,LDL-C and HDL-C between the two groups all showed statistically significant differences after treatment(P0.05).No severe adverse effect was found in the two groups.Conclusion Carvedilol has similar antihypertensive effect as metoprolol,but its efficacy in the regulation of glucose and lipid metabolism is better,besides,it is more suitable for patients with hypertension and metabolic disorders of blood lipids and blood glucose.