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Levels of Insulin-like growth factor-1 and β-endorphin in serum with brain damage in neonatal asphyxia

Ye Yu

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Abstract

Objective To investigate insulin-like growth factor-1(IGF-1) andβ-endorphin(β-EP) levels and their relations to brain damage in neonatal asphyxia.Methods Serum contrations of IGF-1 andβ-EP were detected by radioimmunoassay on day 1,7 after the birth in 60 cases with neonatal asphyxia and on day 1 after the birth in 30 cases normal neonates.The relationship of brain damage with them was analyzed.Results Compared with the control group,IGF-1 of asphyxiated newborns in 1 day was significantly reduced(P0.001). Compared with the control group,β-EP was significantly higher(P0.001).IGF-1 in HIE group was lower than that in a simple group of asphyxia(P0.001);β-EP in HIE group was higher than that in a simple group of asphyxia(P0.001).Conclusion Neonatal asphyxia can lead to the increase of IGF-1 and the increase ofβ-EP. IGF-1 andβ-EP were associted with the brain damage,and there is a negative correlation between IGF-1 andβ-EP.

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Objective To investigate insulin-like growth factor-1(IGF-1) andβ-endorphin(β-EP) levels and their relations to brain damage in neonatal asphyxia.Methods Serum contrations of IGF-1 andβ-EP were detected by radioimmunoassay on day 1,7 after the birth in 60 cases with neonatal asphyxia and on day 1 after the birth in 30 cases normal neonates.The relationship of brain damage with them was analyzed.Results Compared with the control group,IGF-1 of asphyxiated newborns in 1 day was significantly reduced(P0.001). Compared with the control group,β-EP was significantly higher(P0.001).IGF-1 in HIE group was lower than that in a simple group of asphyxia(P0.001);β-EP in HIE group was higher than that in a simple group of asphyxia(P0.001).Conclusion Neonatal asphyxia can lead to the increase of IGF-1 and the increase ofβ-EP. IGF-1 andβ-EP were associted with the brain damage,and there is a negative correlation between IGF-1 andβ-EP.

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Available abstract

Objective To investigate insulin-like growth factor-1(IGF-1) andβ-endorphin(β-EP) levels and their relations to brain damage in neonatal asphyxia.Methods Serum contrations of IGF-1 andβ-EP were detected by radioimmunoassay on day 1,7 after the birth in 60 cases with neonatal asphyxia and on day 1 after the birth in 30 cases normal neonates.The relationship of brain damage with them was analyzed.Results Compared with the control group,IGF-1 of asphyxiated newborns in 1 day was significantly reduced(P0.001). Compared with the control group,β-EP was significantly higher(P0.001).IGF-1 in HIE group was lower than that in a simple group of asphyxia(P0.001);β-EP in HIE group was higher than that in a simple group of asphyxia(P0.001).Conclusion Neonatal asphyxia can lead to the increase of IGF-1 and the increase ofβ-EP. IGF-1 andβ-EP were associted with the brain damage,and there is a negative correlation between IGF-1 andβ-EP.

Key concepts: Asphyxia, Medicine, Brain damage, Radioimmunoassay, Insulin-like growth factor, Asphyxia Neonatorum, Internal medicine, Anesthesia

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