Insulin-like growth factor-1 and calcitonin gene-related peptide levels in blood of neonatal asphyxia related to brain damage.

To explore the effect of two factors for brain damage after asphyxia, analyze the changes of pathophysiological and relation to brain damage. IGF 1 and CGRP levels in peripheral blood were determined by using radioimmunoassay. ① IGF 1 levels among severe asphyxia, slight asphyxia and normal neonates at 1 day were different significantly ( F=11.180,P 0.001). IGF 1 and CGRP levels at 7 days were closed to group of normal neonates and compared to that at 1 day there were significantly different, but IGF 1 was lower in severe than in slight. ② Levels of IGF 1 among mild, moderate and severe HIE decreased gradually, and all were lower than pure asphyxia group, but CGRP rose and were higher than group of normal neonates at 1 day. All that IGF 1 rose and CGRP decreased at 7 days compared to levels at 1 day were significantly different, while IGF 1 was lower than group of normal neonates in severe HIE at 7 days. ③ CGRP levels was higher for neonates with subarachnoid haemorrhage at 1 day. ④ Linear correlation showed IGF 1 negatively correlated with CGRP in neonatal asphyxia and HIE at 1 day. [Conclusions] ①IGF 1 and CGRP influenced the pathophysiological processes of neonatal asphyxia, they were closely related to pathogenestic mechanism of brain damage, protected nerve system. ② CGRP played a role in subarachnoid haemorrhage.