The correlative study on the expression metalloproteinase-13 and interleukin-6 in Osteoarthritis

Objectives To explore the correlative expression of metalloproteinase-13(MMP-13)and interleukin-6(IL-6)in patients with osteoarthritis.Methods The expressions of MMP-13 and IL-6 protein in chondrocytes and synoviocytes of 60 patients with osteoarthritis and 20 cases as normal control groups were determined with immunohistochemical method,and expressive correlations in osteoarthritis were analyzed.Results IOD of MMP-13 protein in OA group was significantly higher than that in normal control groups(P0.01),IOD of IL-6 protein in OA group was higher than that in normal control groups(P0.05),and there was positive correlation between the MMP-13 protein and IL-6 protein expression(r=0.827,P0.01)in OA group.Conclusion It was close relation between the expression of MMP-13 and the OA occurrence and progress.High levels of MMP-13 in chondrocytes and synoviocytes of osteoarthritis mould be activated and up-regulated by a series of inflammatory cytokines such as IL-6,etc.