Clinical Effects of Thalidomide and Dexamethasone in the Treatment of Multiple Myeloma

Objective: To explore the responce and safety of the lidomide combined with dexamethasone in the treatment of multiple myeloma.Methods: From January 2003 to January 2006,40 patients were randomized into the study group for which thalidomide and dexamethasone were administered,and control group for which thalidomide alone was given.Results: The overall response rate was 85% for the study group which was significantly higher than the 55% in the control group.The improvement of other parameters such as blood nutine,sedimentation rate,serum calcium and M protein were more significant for the study group.The dverse effects were minimal.Conclusion: The combined thalidomide and dexamethasone treatment offered good therapeutic effects for multiple myeloma,with slight toxicities.