The change and the diagnostic and prognostic values of measurements of cardiac troponin I,high sensitive C reactive protein and B-type natriuretic peptide before or after treatment in patients with heart failure

Objective To explore the diagnostic and prognostic values of measurements of cardiac troponin I(cTnI),high sensitive C reactive protein(hs-CRP) and B-type natriuretic peptide(BNP) in patients with heart failure(HF).Methods 128 clearly diagnosed HF patients of different etiology and different classification of cardiac function were determined on admission to hospital,48 hours after treatment and at hospital discharge.Their serum cTnI,hs-CRP and plasma BNP levels on pre-treatment and after treatment were determined and compared to observe,with 50 healthy subjects as controls.The patients were followed up to be observed the recurrence of cardiac events.Results In the HF patients with different classification of cardiac function and the controls,serum cTnI,hs-CRP and plasma BNP levels were compared,and the differences were statistically significant.The worse the heart function was,the higher the concentration was(P0.01).They were compared in the three different periods of treatment in HF patients,and there was a substantially difference(P0.01).The joint measurement of serum cTnI,hs-CRP and plasma BNP levels in HF patients had an early sensitivity of 94.5%,and it was obviously better than a single measurement(P0.01).In the follow-up patients of the cardiac events group,serum cTnI,hs-CRP and plasma BNP concentrations at hospital discharge were markedly higher than those in the non-cardiac events group(P0.01).Conclusions Serum cTnI,hs-CRP and plasma BNP concentrations in patients with HF significantly increase,and the clinical diagnosis and prognosis of the three combined measurements in patients with HF have important significance.