Study of the Influence of Intermittent Exercise on the Expression of c-fos Protein in Hippocampus of Rat

This is to study the effect of intermittent exercise on the expression of c-fos protein in hippocampus.Male SD rats were randomly divided into two groups:control group and intermittent exercise group.To establish the intermittent swimming exercise models in rat,and detect the change of the expression of c-fos positive cells in hippocampus by using ABC immunohistochemistry means,then analyze the image and data by imaging analyzing system and statistic software.The result shows that: after exercise,the density of c-fos positive cells were significantly higher in the different regions of hippocampus,with significant difference as compared with the control group(P0.01);in CA2,the expression of c-fos positive cells were increased obviously,gets up to the top at 05h,and then descend;In CA3,the express density of c-fos positive cells is the highest,the top at 1h,and then descend rapidly;in CA1,the express density of c-fos positive cells is small relatively,the top at 1h,and then descend slowly.Conclusion:intermittent exercise could affect the expression of c-fos protein in hippocampus,and the expression of c-fos protein was timelines;the express density and phase of c-fos positive cells in the different regions of hippocampus have significant difference due to the tolerance of ischemia and anoxia.