Expression and clinical significances of BCL-2 and P53 in non-small cell lung cancer

Objective To investigate the expression and its significance of P53 and BCL-2 in non-small cell lung cancer(NSCLC).Methods The expression of P53 and BCL-2 was evaluated in 60 specimens of NSCLC and 10 specimens benign lung tissues by immunohistochemistry S-P method.Results The positive rate of BCL-2 in NSCLC was(51.7%),which was significantly higher than that of BCL-2 in benign tissues(0.0%)(P0.05);But no statistically significant difference was found between clinical stage Ⅰ~Ⅱ(48.0%) and clinical stage Ⅲ~Ⅳ(54.3%)(P0.05).The positive rate of P53 in NSCLC was(56.7%),which was significantly higher than that of P53 in benign tissues(0.0%)(P0.05);The positive rate of P53 in clinical stage Ⅲ~Ⅳ NSCLC(71.4%) was significantly higher than that in stage Ⅰ~Ⅱ(36.0%)(P0.05).Conclusion The BCL-2 and P53 gene may participate in carcinogenesis and development of lung cancer and it could be identified as a marker to diagnosis and prognosis of it.