2011•Zhongguo xiao-yiRequires access
Significance of combined detection of serum CA125,AFP and CA199 in diagnosis of ovarian carcinoma
Wang Xin-me
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Abstract
Objective To study the significance of combined detection of serum levels of CA125,AFP and CA199 in diagnosis of ovarian carcinoma.Methods The serum levels of CA125,AFP and CA199 in 59 patients with ovarian carcinoma,49 patients with benign ovarian tumor and 50 healthy women as control were measured by Elctrochemillum ignescent immunoassay(ECLIA).Results The serum levels of CA125,AFP and CA199 in the patients with ovarian carcinoma were significantly higher than those in patients with benign ovarian tumor or healthy women(P0.05).In the ovarian carcinoma group,the positive rates of CA125,AFP and CA199 were 79.67%,47.4% and 44.0% respectively.The sensitivity of combined detection of CA125 and AFP was 89.8%,and the sensitivity of combined detection of CA125 and CA199 was 81.3%.The sensitivity of combined detection of the three kinds of tumor markers was 93.2%.Conclusions The significance of combined detection of serum levels of CA125,AFP and CA199 is clinically important in the diagnosis of ovarian carcinoma.