Effect of Benazepril on Plasma Biomarkers of Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus Complicated with Hypertension

Objective: To explore the effect of benazepril on plasma biomarkers of endothelial dysfunction in patients with type 2 diabetes mellitus complicated with hypertension.Methods: Thirty-two patients with type 2 diabetes mellitus complicated with hypertension were treated with benazepril[(10～20)mg/d]for 6 months.Twenty matched healthy people were taken as control.Before treatment and after 6 months of treatment,the fasting blood glucose(FBG),postprandial blood glucose(2 h-PBG),thromodulin(Tm),von Willebrand factor and nitric oxide(NO)as well as systolic pressure(SBP)and diastolic pressure(DBP)were determined.The reactive congestion and nitroglycerin-induced dilation of the brachial artery were assayed with high-resolution ultrasound.Results: After 6 months of treatment in all patiens,FBG,2 h-PBG and diameter in brachial artery after summing glyceryltrinitrate showed no change markedly.The plasma levels of Tm,von Willebrand factor were reduced and NO was increased obviously than before treatment.The diameter in brachial artery in responding to reactive hyperaemia was improved greatly than before treatment.After 6 months of treatment,SBP and DBP were all cut down obviously than before treatment.Conclusion: Benazepril effectively reduces blood pressure,improves endothelial-dependent vasodilatation concomitantly with a decrease in the plasma levels of Tm,von Willebrand factor and an increase in the plasma levels of NO in patients with type 2 diabetes mellitus complicated with hypertension.