Pharmacokinetics of levofloxacin hydrochloride tablets after a high oral dose

OBJECTIVE To study the pharmacokinetics of levofloxacin hydrochloride tablets in healthy volunteers after a high oral dose of 750 mg.METHODS A single oral dose of 200 mg and 750 mg of levofloxacin hydrochloride were given to 10 healthy volunteers.The concentrations of levofloxacin in plasma were determined by HPLC.The pharmacokinetics parameters were calculated by DAS program.RESULTS After a single dose of 200 mg and 750 mg levofloxacin hydrochloride,the pharmacokinetics of levofloxacin were as follows: C_(max)were((2.1)±(0.3))mg·L~(-1) and((5.7)±(0.5))mg·L~(-1);T_(max)were((1.1)±(0.2))h and((1.5)±(0.4))h;t_(1/2α) were((3.1)±(1.3))h and((3.2)±(1.9))h;t_(1/2β) were((11.6)±(4.4))h and((10.9)±(4.4))h;AUC_(0-t) were ((13.2)±(1.8))mg·h·L~(-1) and((60.5)±(6.0))mg·h·L~(-1) respectively.CONCLUSION The pharmacokinetics of 750 mg levofloxacin in healthy volunteers fit to two compartment model with 1st order elimination.