Efficacy of compound enalapril and compound valsartan in patients with mild and moderate primary hypertension

Objective: To evaluate the efficacy of compound enalapril and compound valsartan in patients with mild and moderate primary hypertension by monitoring dynamic blood pressure.Methods: In an open-labeled,randomized and crossover designed trial,40 patients with primary hypertension [mean age 51.54±8.12y,defined as mean sitting diastolic blood pressure(SeDBP) between 95mmHg and 114mmHg and 24h mean DBP≥82mmHg with dynamic blood pressure monitoring] were enrolled.After 2 weeks washout period,they were treated with either enalapril 10mg/hydrochlorothiazide 12.5mg or valsartan 80mg/hydrochlorothiazide 12.5mg,once-daily for 8 weeks.At the end of the washout period and the treatment period,a non-invasive 24-h dynamic BP monitoring(ABPM) was performed and laboratory examination was conducted.Results: Dynamic monitoring of blood pressure indicated a significant reduction in average 24-h systolic blood pressure(SBP) and DSP after treatment in the two groups(P0.001).The degree of reduction in SBP and DBP was more conspicuous in compound enalapril group than in compound valsartan group,but no statistical difference was found between the two groups.Trough/peak(T/P) SBP and T/P DBP reduced by 60.45% and 53.24%,respectively,in the compound enalapril group;and 85.22% and 78.96%,respectively,in the compound valsartan group.T/P in the two groups was more than 50% and this hypotensive effect maintained for 24h.The adverse reactions were mild.Conclusion: Compound enalapril and compound valsartan can effectively lower DSP and SBP in patients with mild and moderate primary hypertension.Administration once daily can maintain 24-h steady reduction in BP.