Application of Thinprep liquid based cytology in large-scale screening of cervical cancer in Zhongshan city

Objective:To evaluate the application value of Thinprep liquid based cytologic test(TCT) in large-scale screening of cervical cancer.Methods:The cervical cells of 44 936 cases were detected by TCT,then TBS classification was performed;the cases with cervical lesions above atypical squamous cells of undetermined significance(ASCUS)/atypical glandular cells(AGC) were designed as cytological positive cases,and colposcopic multiple punch biopsy was conducted,the cases with cervical intraepithelial neoplasia(CIN) or above CIN lesions were designed as histopathological positive cases,the pathological results were designed as gold standards,then the cytological results were compared with pathological results after biopsy.Results:Among 44 936 cases,1 413 cases were diagnosed as cytological positive cases,the total detection rate was 3.14%,including 202 cases with LSIL(0.45%),128 cases with HSIL(0.28%),4 cases with squamous cell carcinoma(SCC)(0.09‰),one case with AC(0.02‰),119 cases with ASC-H(0.27%),919 cases with ASCUS(2.05%),and 40 cases with AGC(0.09%).A total of 761 cases underwent pathological examination,then the results were compared with cytological results,the pathological positive rates of ACC,AC,HSIL,LSIL,ASC-H,ASCUS,and AGS detected by TCT were 100.00%(4/4),100.00%(1/1),90.40%(66/73),47.27%(52/110),67.69%(44/65),16.32%(79/484),and 41.66%(10/24),respectively.The pathological accurate rates of SCC,AC,HSIL,and LSIL detected by TCT were 100.00%(4/4),100.00%(1/1),60.01%(46/73),and 37.20%(41/110),respectively.Conclusion:TCT is a convenient and power-efficient screening method for cervical cancer and cervical precancerous lesion,which is useful for early diagnosis and early treatment of cervical cancer and cervical precancerous lesion.