Comparison of cervical ThinPrep cytology test and histopathology detection

Objective To evaluate ThinPrep cytology test(TCT) in diagnosis of cervical intraepithelial neoplasia.Methods The results of thinprep cytology test from 11 922 patients(aged from 17 to 84) were analyzed retrospectively.And the data from cervical biopsies and surgical excision histology were compared.Results Three hundred and twenty-one positive cases with abnormal epithelial cells were diagnosed by TCT(2.62%).Among the 312 cases,173 cases were diagnosed with atypical squamous cells of undetermined significance(ASCUS),12 cases with atypical squamous cells,cannot exclude HSIL(ASC-H),76 cases with low-grade squamous intraepithelial lesion(LSIL),48 cases with high-grade squamous intraepithelial lesion(HSIL) and 3 cases with squamous cell carcinoma(SCC).However,only 157 of 321 cases were carried out cervical biopsy. The biopsy results from 59 cases with ASCUS showed that 17 cases(28.8%) were negative,15 cases (25.4%) with human papilloma virus(HPV) infection,13 cases(22.0%)with cervical intraepithelial neoplasiaⅠ(CINⅠ),11 cases(18.6%) with CINⅡand 3 cases(5%) with CINⅢ.In comparison with TCT and cervical histology results,the rate of consistent results were 35.2%(19/54) for LSIL, 67.7%(21/31)for HSL,100%(3/3) for SCC respectively.But HSIL with histology has higher consistency than that of LSIL with histology(x~2=8.38,P0.01).The consistent diagnostic results from cervical biopsy and surgical excision was 75%(27/36).Conclusion Diagnosis of HSIL by TCT has a good consistent with cervical histology.But the diagnosis of ASCUS with TCT,is more difficult. Improving the accuracy diagnosis of ASCUS by TCT is an important way for clinical applications.