Expression and clinical significance of HER-2 in gastric carcinoma tissues

Objective To investigate the expression and clinical significance of HER-2 in gastric carcinoma.Methods The expression of HER-2 in the tumor tissue from 90 patients with gastric carcinoma was examined by immunohistochemically methond.The relationship between HER-2 expression and the clinical pathologic parmeters was analyzed.Results The positive rates of HER-2 in gastric carcinoma was14.4%(13/90).The expression of HER-2 was more frequently detected in the age ≥65 than in the age65.The expression of HER-2 was more frequently detected in the low differentiation than in the high differentiation.The expression of HER-2 was more frequently detected in the Ⅲ and Ⅳ stage than in the I and Ⅱstage.The expression of HER-2 was more frequently detected in the gastric carcinoma with regional lymph metastasis than without regional lymph metastasis.The expression of HER-2 was more frequently detected in gastric cancer with carcinoma diameter≥5 cm than that with carcinoma diameter5cm,all groups were significant different(p0.05).Conclusions The expression of HER-2 was significantly correlated with the clinicopathological factors such as diameter、differentiation、stage and regional lymph metastasis.HER-2 may play important roles in development of gastric carcinoma.