Curative Efficacy of MTX Combined with Mifepristone and Traditional Chinese Medicine in Conservative Treatment of Ectopic Pregnancy

Objective To investigate the curative efficacy of MTX combined with mifepristone and traditional Chinese medicine in conservative treatment of ectopic pregnancy.Methods Ninety patients with ectopic pregnancy received conservative treatment with intramuscular injection of 50 mg MTX every other day(3 times)alone(MTX group,n=44)or in combination with 50 mg mifepristone twice daily for 4 days and traditional Chinese medicine decoction(15 g Radix Salviae Miltiorrhizae,15 g Radix Paeoniae Rubra,9 g peach kernel,6 g trigonous,6 g zedoary,3 g Magnolia and 3 g fructus aurantii immaturus) twice daily for 7 days(combination group,n=46).Changes in blood β-HCG levels and curative effects were compared between the two groups.Liver and kidney functions were measured and blood routine examination was performed once.Then,blood β-HCG levels were detected and pelvic mass was reexamined once a week.Drug withdrawal was performed when β-HCG level returned to normal.Results After 1 month of follow-up,the total effective rate in MTX group was significantly lower than that in combination group(75.0% vs 89.1%,P0.05).Moreover,the time to β-HCG dropping to normal in MTX group was significantly longer than that in combination group [(4.5±0.9) weeks vs(3.2±1.0)weeks,P0.05).Conclusion The conservative treatment with MTX,mifepristone and tradit-ional Chinese medicine is safe and reliable for treating ectopic pregnancy.