Clinical analysis on 449 cases of preterm premature rupture of membranes

Objective To explore the characters of preterm premature rupture of membranes(pPROM),and analyze the influence of different gestational weeks of pPROM on the delivery route and perinatal outcomes.Methods A retrospective study of 449 cases of pPROM in the hospital from Jan.2003 to Dec.2007 was conducted.Results The prevalence of PROM among all pregnant women was 14.3%,while pPROM was 3.3%.The correlative factors occurred in the 449 cases of pPROM as the following proportion:abortion and induced abortion for 41.0%,uncertained reasons 23.8%,multiple pregnancy 10.4%,history of infection 9.8%.Among the 437 cases of delivered pPROM,the cesarean section rate in 32～34+6 gestational week group was higher than that in the 28～31+6 week or 35～36+6 week group(P0.0166),while 28～31+6 week group presented no difference from that in the 35～36+6 week group(P0.0166).Among 490 newborns,delivery routes had no different effect on the newborn outcome in the 32～34+6 gestational week group.The transfer rate to PICU,the incident of neonatal asphyxia and low body weight in the 28～31+6 gestational week or 32～34+6 gestational week groups were higher than that in the 35～36+6 gestational week group(P0.0166).Conclusions The history of abortion and induced abortion,infection,uncertained reasons may be the major related factors of pPROM.Cesarean delivered is not the optimal delivery route to improve newborn outcomes.Newborn outcomes are associated to gestational weeks.