2008•The Journal of Pharmaceutical PracticeRequires access

Determination of cryptotanshinone and tanshinone IIA in Danshentong buccal tablets by HPLC

Jiuhong Wu

Abstract

Objective: To develop a HPLC quantitative method for the determination of cryptotanshinone and tanshinone ⅡA in Danshentong buccal tablets.Methods:The chromatographic conditions include column C18(Agilent ZORBAX Eclipse XDB-C18,4.6×150 mm,5 μm),mobile phase:acetonitrile-water(5545),flow rate 1.0 mL/min and detection wavelength 327 nm.Results:The regresstion equation of cryptotanshinone and tanshinone ⅡA was Y=0.000 270 9X+0.001 090,r=0.999 9,Y=0.000 255 6X+0.001 055,r=0.999 9.The linear range was 0.036 00～1.440 μg and 0.030 00～1.200 μg.The average recovery of cryptotanshinone and tanshinone ⅡA were 101.7%(RSD 0.28%),100.8%(RSD 0.50%)respectively.Conclusion:The method was sensitive,rapid and accurate.

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Key concepts: Chromatography, Chemistry, High-performance liquid chromatography, Buccal administration, Linear range, Detection limit, Pharmacology, Medicine