Clinical Pathological Analysis of Primary Gastrointestinal Lymphoma

Objective To analyze the clinical presentation and the features of pathology and the immunophenotype of immunohistochemical staining. Methods The clinical,pathologic features of 78 cases of primary gasrtointestinal lymphoma were analysed restrospectively. A panel of antibodies including CK,LCA,CD3,UCHL1,CD20,CD79a,CD5,CyclinD1,CD10,BCL6,MUM1,CD30,CD56,Ki-67 were detected by im- munohistochemical staining(IHC). EBER was detected by in situ hybridization(ISH). Results The initial symptoms or signs included abdom- inal pain,abdominal mass,hematochezia. 22 cases located in gaster,24 in small intestine,15 in ileocecal junction,12 in colon,5 in rectum. All cases were positive for LCA,69 for CD20 and CD79a,3 for CD5 and CyclinD1,9 for CD3 and CD45RO,1 for CD30,1 for CD56,Ki-67 about 20% to 70%,and all cases were negative for CK by IHC,2 cases were positive for EBER by ISH. According to the world health organization (WHO)classification,36 cases were mucosa associated lymphoid tissue malignant lymphoma(MALT-ML),30 were diffuse large B-cell lym- phoma(DLBCL),3 were mantle cell lymphoma(MCL),6 were peripheral T cell lymphoma,unspecified(PTCL-U),1 was enteropathy associat- ed T cell lymphoma(ETCL),1 was extra nodal NK/T cell lymphoma,nasal type(ENKL)and 1 was anaplastic large cell lymphoma(ALCL). Conclusion B cell lymphoma is the most common type in primary gastrointestinal lymphoma,T cell lymphoma is rare. It is very difficult to be identified from gastrointestinal carcinoma by clinical presentation. The diagnosis of primary gastrointestinal lymphoma depends on biopsy or surgical specimen,with immunohistochemical staining and sometimes should be detected by ISH.