Application of serum procalcitonin and C-reactive protein level in the diagnosis of emergency sepsis

Objective: To investigate the application of the combined determination of serum procalcitonin(PCT) and C-reactive protein(CRP) in the diagnosis of emergency sepsis. Methods: Two hundred cases of emergency patients who were treated in our hospital from January 2012 to January 2014 were divided into a mild sepsis group(n=43), a severe sepsis group(n=25) and the other group(n=132), and 30 healthy subjects were selected as a control group. ELISA method was used to detect the change of serum PCT and CRP levels in patients and the values of serum PCT and CRP were used for predicting their relationship with emergency sepsis. Results: Serum PCT and CRP levels in the mild sepsis and severe sepsis groups were higher than those in other group and the control group, and PCT and CRP levels in severe sepsis group were higher than those in the mild sepsis group(P0.05). PCT and CRP levels were positively correlated with sepsis severity(rPCT=7.453, rCRP=7.453, P0.05). Logistic regression analysis showed that risk factors of emergency sepsis appeared as blood coagulation dysfunction and the enhanced levels of PCT and CRP. Conclusion: The determination values of serum procalcitonin and C-reactive protein levels are of significance in the diagnosis of emergency sepsis, which can be used as indicators for the diagnosis of emergency sepsis.