Association of serum uric acid level with metabolic syndrome and its components

Objective:To analyze the association of serum uric acid(SUA) level with prevalence and the risk of metabolic syndrome(MS) and its components.Methods: A random,multi-stage cross-sectional study was conducted among adults(18～74 years old) in a rural population in Gaoyou,Jiangsu Province.Blood samples were collected for testing blood glucose,lipid profile and SUA and the relationship between SUA and MS was analysed.A total of 4 493 subjects(2 101 men,2 392 women) are enrolled in our study.Results: ①The mean uric acid level was significantly lower in women than men[(338.41 ± 87.99) vs.(255.01 ± 75.08)μmol/L,P 0.01].Prevalence of MS was elevated with the increasing SUA level.② SUA level increased significantly with the increaseing number of MS components for both gender.Under a low SUA level,women had higher incidence of MS compared with men.③ After adjustment of age,smoking status,alcohol consumption and estimated glomerular filtration rate(eGFR),SUA was positively correlated with waist,blood pressure,fasting serum glucose and total triglyceride(TG),and inversely correlated with high density lipoprotein cholesterol(HDL-C) while waist and TG had stronger correlation with SUA than other MS components.④ Logistic analysis showed that SUA was an independent predictor on the risk factor for incidence of MS and its components.The OR(95%CI) value of hyperglycemia for women was higher in all the four quartiles of SUA levels than men.Conclusion: There is a significant association between serum uric acid level and metabolic syndrome,as well as its components.The risk of hyperglycemia predicted by serum uric acid levels is greater in women than men.