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2006•The Practical Journal of CancerRequires access

Expression of Epidermal Growth Factor and Epidermal Growth Factor-Receptor and its Significance in Colorectal Cancer

Lin Hon

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Abstract

Objective To investigate the expression of epidermal growth factor(EGF)and epidermal growth factor-receptor(EGF-R)and its significance in colorectal cancer.Methods The expression of EGF and EGF-Rwas detected by SP immunohistochemical method in 10 cases of normal colorectal membrane and 64 cases of colorectal cancer.Results The expression of EGF and EGF-R were both negative in normal colorectal membrane,but were 51% and 66%,respectively,in colorectal cancer,showing a significant difference between the two groups.There was a positive correlation between the expression of EGF and EGF-R in colorectal cancer.Conclusion The EGF and EGF-R play an important role in the carcinogenesis and development of colorectal cancer.

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Objective To investigate the expression of epidermal growth factor(EGF)and epidermal growth factor-receptor(EGF-R)and its significance in colorectal cancer.Methods The expression of EGF and EGF-Rwas detected by SP immunohistochemical method in 10 cases of normal colorectal membrane and 64 cases of colorectal cancer.Results The expression of EGF and EGF-R were both negative in normal colorectal membrane,but were 51% and 66%,respectively,in colorectal cancer,showing a significant difference between the two groups.There was a positive correlation between the expression of EGF and EGF-R in colorectal cancer.Conclusion The EGF and EGF-R play an important role in the carcinogenesis and development of colorectal cancer.

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Available abstract

Objective To investigate the expression of epidermal growth factor(EGF)and epidermal growth factor-receptor(EGF-R)and its significance in colorectal cancer.Methods The expression of EGF and EGF-Rwas detected by SP immunohistochemical method in 10 cases of normal colorectal membrane and 64 cases of colorectal cancer.Results The expression of EGF and EGF-R were both negative in normal colorectal membrane,but were 51% and 66%,respectively,in colorectal cancer,showing a significant difference between the two groups.There was a positive correlation between the expression of EGF and EGF-R in colorectal cancer.Conclusion The EGF and EGF-R play an important role in the carcinogenesis and development of colorectal cancer.

Key concepts: Epidermal growth factor, Colorectal cancer, Epidermal growth factor receptor, Immunohistochemistry, Cancer, Carcinogenesis, Cancer research, Mouse model of colorectal and intestinal cancer

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