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1993•Chinese Journal of Gastroenterology and HepatologyRequires access

DETECTION OF EPIDERMAL GROWTH FACTOR AND EPIDERMAL GROWTH FACTOR RECEPTOR IN COLORECTAL CANCERS

Liu Gl

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Abstract

We immunohistochemically examined expression of EGF and EGF-R in 52 colorectal cancer tissues and 18 normal colon tissues. EGF and EGF-R positive rate were 22. 2% and 16. 7% in normal colon tissues,67. 3% and 61. 5% in colorectal cancers, The positive rate of EGF and EGF-R in colorcetal cancer significantly higher than that in normal tissues (P0. 05). the positive rate of EGF and EGF-R in advance cancers were higher than in early stage cancer. Expression of EGF or EGF-R was no relation to age,sex or location of cancer, Our results suggests that part colorectal cancer have overexpression of EGF and EGF-R,EGF and EGF-R autocrine may contribute to the growth of colorectal cancer.

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What this paper is about

We immunohistochemically examined expression of EGF and EGF-R in 52 colorectal cancer tissues and 18 normal colon tissues. EGF and EGF-R positive rate were 22. 2% and 16. 7% in normal colon tissues,67. 3% and 61. 5% in colorectal cancers, The positive rate of EGF and EGF-R in colorcetal cancer significantly higher than that in normal tissues (P0. 05). the positive rate of EGF and EGF-R in advance cancers were higher than in early stage cancer. Expression of EGF or EGF-R was no relation to age,sex or location of cancer, Our results suggests that part colorectal cancer have overexpression of EGF and EGF-R,EGF and EGF-R autocrine may contribute to the growth of colorectal cancer.

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Available abstract

We immunohistochemically examined expression of EGF and EGF-R in 52 colorectal cancer tissues and 18 normal colon tissues. EGF and EGF-R positive rate were 22. 2% and 16. 7% in normal colon tissues,67. 3% and 61. 5% in colorectal cancers, The positive rate of EGF and EGF-R in colorcetal cancer significantly higher than that in normal tissues (P0. 05). the positive rate of EGF and EGF-R in advance cancers were higher than in early stage cancer. Expression of EGF or EGF-R was no relation to age,sex or location of cancer, Our results suggests that part colorectal cancer have overexpression of EGF and EGF-R,EGF and EGF-R autocrine may contribute to the growth of colorectal cancer.

Key concepts: Epidermal growth factor, Colorectal cancer, Autocrine signalling, Epidermal growth factor receptor, Heparin-binding EGF-like growth factor, Cancer, Internal medicine, Cancer research

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DETECTION OF EPIDERMAL GROWTH FACTOR AND EPIDERMAL GROWTH FACTOR RECEPTOR IN COLORECTAL CANCERS — Research Paper | ScholarLens