2003•Journal of Qilu OncologyRequires access

Expression of VEGF and the Relationship Between It and MVD in Breast Carcinoma

Ying Jiang

Abstract

Objective To clarify the relationship between the expression of vascular endothelial growth factor(VEGF) and the angiogenesis,pathological factors in breast carcinoma.Methods The S-P immunohistochemistry and VEGFmRNA situ hybridization were used.Results The positive rate of VEGF in breast carcinoma was higher than that in normal tissue,P0.05.The expression of VEGF was closely related to pathological grade and lymphatic metastasis,P0.01.P0.05,respectively.A significantly higher microvessel density(MVD) was observed in the breast carcinoma with positive expression of VEGF compared with that of the negative expression,P0.01.Conclusions The up-regulation of VEGF has an important role in angiogenesis,growth and metastases of breast carcinoma.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Breast carcinoma, Pathological, Immunohistochemistry, Angiogenesis, Vascular endothelial growth factor, Carcinoma, Pathology, VEGF receptors