ScholarLens Back to search
2001•Unpublished venueRequires access

THE EXPRESSION OF Bcl-2 AND P53 IN ENDOTHELIAL CELLS AFTER FOCAL CEREBRAL ISCHEMIA/REPERFUSION IN RATS

Yunliang Guo

Open publisher page 0 citations

Abstract

Objective To study the expression of Bcl 2 and P53 proteins of endothelial cells after focal cerebral ischemia/reperfusion in rats. Methods Coronal sections of brain were analysed using immunohistochemical staining technic after reperfusion (2,6,12,24 hours and 2,3,7,14,21 days) to observe the expression of Bcl 2 and P53 proteins. Results The Bcl 2 protein began to express at 2h after reperfusion, peaked at 12-24h, and declined gradually to controlled level at 14d. The P53 protein began to express at 6h after reperfusion, peaked at 24-48h, and declined successfully to controlled level at 7d. The expression peaked ime of P53 protein was 12h-1d later than that of Bcl 2 protein. Conclusion Bcl 2 and P53 proteins take a great role in the process of apoptosis of endothelial cells. [

About this research paper

What this paper is about

Objective To study the expression of Bcl 2 and P53 proteins of endothelial cells after focal cerebral ischemia/reperfusion in rats. Methods Coronal sections of brain were analysed using immunohistochemical staining technic after reperfusion (2,6,12,24 hours and 2,3,7,14,21 days) to observe the expression of Bcl 2 and P53 proteins. Results The Bcl 2 protein began to express at 2h after reperfusion, peaked at 12-24h, and declined gradually to controlled level at 14d. The P53 protein began to express at 6h after reperfusion, peaked at 24-48h, and declined successfully to controlled level at 7d. The expression peaked ime of P53 protein was 12h-1d later than that of Bcl 2 protein. Conclusion Bcl 2 and P53 proteins take a great role in the process of apoptosis of endothelial cells. [

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the expression of Bcl 2 and P53 proteins of endothelial cells after focal cerebral ischemia/reperfusion in rats. Methods Coronal sections of brain were analysed using immunohistochemical staining technic after reperfusion (2,6,12,24 hours and 2,3,7,14,21 days) to observe the expression of Bcl 2 and P53 proteins. Results The Bcl 2 protein began to express at 2h after reperfusion, peaked at 12-24h, and declined gradually to controlled level at 14d. The P53 protein began to express at 6h after reperfusion, peaked at 24-48h, and declined successfully to controlled level at 7d. The expression peaked ime of P53 protein was 12h-1d later than that of Bcl 2 protein. Conclusion Bcl 2 and P53 proteins take a great role in the process of apoptosis of endothelial cells. [

Key concepts: Immunohistochemistry, Apoptosis, Ischemia, P53 protein, Reperfusion injury, Protein expression, Pathology, Biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
THE EXPRESSION OF Bcl-2 AND P53 IN ENDOTHELIAL CELLS AFTER FOCAL CEREBRAL ISCHEMIA/REPERFUSION IN RATS — Research Paper | ScholarLens