Clinical study of left ventricular diastolic function in patients with heart disease by M-mode color Doppler echocardiography

Objective To evaluate the value and accuracy of M-mode color Doppler echocardiography for detecting left ventricular diastolic function in patients with cardiac disease. Methods The rate of left ventricular filling flow propagation (Vp) and the early -diastolic peak velocity of the mitral annulus(E) was measured in normal subjects(n=40)and in patients with cardiac disease (n=40). All the patients had abnormal left ventricular diastolic function confirmed by isotope-angiography test. Results ① The Vp was significantly lowered in patients with cardiac disease than in normal subjects(P 0.01).Furthermore, the Vp was significantly reduced in 12 patients with E/A≥1(pseudonormalized transmitral flow pattern); ②In 40 patients, the correlation between the Vp and PFR obtained by isotope-angiography test, and the correlation between Vp and E were good(r= 0.83, 0.80 respectively,P 0.01).Conclusions The Vp may provide an accurate method for evaluating left ventricular diastolic function and can identify the pseudonormalization of E/A.