Ultrasound-guided hot lipiodol with ~(90)Yintratumor intra-tumor injectionon on liver cancer

Objective: To observe the effect of hot lipiodol with~ 90Y intratumor injection for treatment of liver cancer. Methods: 12 patients in treatment group and 10 patients in control group were performed ultrasonically guided hot lipiodol injections (treatment group) and common lipiodol injections(control group)with radiopharm-aceutical Yttrium-90 therapy. Results: No side-effect and no significant complication were observed. The tumor sizes showed a reducing trend at different time. In treatment group,the tumor growth was-0.47±0.17 at the 30th day after treatment, and significantly lower than that in control grout(-0.18±0.22) (P0.01).The tumor necrosis range was less than 40% in control group. The tumor necrosis rate in treatnent group was 72%,81% and 87% at the 3th,7th and 30th day respective. There was a significant difference between the two groups(P0.01). There was a positive correlation between the necrosis rate and the time in treatment group (P0.05) Conclusion: Intratumor injection of hot lipiodol with~ 90 Y is a safe, feasible and effective method to treat liver cancer.