2005•Clinical EndoscopyRequires access
Expression of Cyclooxygenase-2 and p53 Protein in Colonic Adenoma with Malignant Change
Seok‐Hyun Kim, Jae-Hoon Jung, Yoon-Sae Kang, Yeon-Soo Kim, Ki-Oh Park, Yeum-Seok Lee, Seon-Mun Kim, Seung-Won Seo, Jae-Kyu Seong, Byung-Seok Lee, Hyun Yong Jeong, Gyu-Sang Song
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Abstract
Background/Aims: The aim of this study was to investigate the value of expression of COX-2 and p53 protein in colonic adenoma with or without malignant change. Methods: We studied twenty-five cases of colonic adenoma with malignant change and twenty-five cases of colonic adenoma without malignant change treated by colonoscopic polypectomy in Chungnam National University Hospital from January, 1999 to July, 2002. We compared the expression of COX-2 and p53 protein by immunohistochemical stain in both group. Results: In immunohistochemical staining, the expression of COX-2 was demonstrated 68.0% (17 of 25) of colonic adenoma with malignant change and not different with that of colonic adenoma without malignant change. The overexpression of p53 protein was detected immunohistochemically in 88.0% (22 of 25) of colonic adenoma with malignant change and 32% (8 of 25) of colonic adenoma only (p＜0.05). Conclusions: The degree of COX-2 expression was similar in colonic adenoma and colonic adenoma with malignant change, but the expression of p53 in colonic adenoma with malignant change was significantly higher (p＜0.05). These results suggest COX-2 might operate on early step of adenoma-carcinoma sequence. Also these results remind us that mutation of p53 gene operates on the late step of adenoma-carcinoma sequence.