Effect of Shenfu injection combined with low dose hydrocortisone on immune function and expression of inflammatory factors in patients with severe sepsis

Objective To explore the effect of Shenfu injection combined with low dose hydrocortisone on immune function and expression of inflammatory factors in patients with severe sepsis.Methods 65 elderly patients with severe sepsis were randomly divided into the experiment group( 33cases) and the control group( 32 cases).The experiment group received Shenfu injection combined with low dose hydrocortisone,while the control group received basic treatment( with antibiotic susceptibility + early fluid resuscitation + correct acidosis).The levels of TNF-α,IL-1β,IL-10 and T lymphocyte subsets were observed before and after the treatment.Results There was no significant difference in TNF-α,IL-1β,IL-10 and T lymphocyte subsets before treatment between the two groups( P 0.05).In the control group,there was no significant difference in TNF-α,IL-1β,IL-10 and T lymphocyte subsets1-day after the treatment.The levels of TNF-α,IL-1β and IL-10 decreased and T lymphocyte subsets increased 3 and5 days after the treatment( P 0.05).There were 17 cases improved,8 cases progressed and 7cases died in the control group,while there were 24 cases improved,7 cases progressed and 2 cases died in the experiment group 7days after the treatment( χ2= 7.74,P = 0.03).Conclusion The combination therapy of Shenfu injection and low dose hydrocortisone can improve the immune function in patients with severe sepsis more effectively.