Expression and Significance of DOG-1 in Gastrointestinal Stromal Tumors

Objective To investigate the expression of DOG-1 in gastrointestinal stromal tumors(GIST) and its diagnostic significance.Methods Immunohistochemistry staining was performed on clinical specimens from 61 patients with GIST.Cross link between CD117 and DOG-1 expressions was examined to explore the value of DOG-1 on GIST diagnosis and prognosis.Results In very low and low risk groups of GIST,95.2%(20/21)and 90.5%(19/21)specimens could detect positive expression of CD117 and DOG-1,respectively.In the groups of moderate and high risk,positive expressions of CD117 and DOG-1 were 100.0%(40/40) and 97.5%(39/40),respectively.There was no relationship between the expression of CD117 and that of DOG-1.The expression of DOG-1 in GIST was not related to tumor initiation location,tumor size,clinical classification or patient age.DOG-1-negative expression was remarkably correlated with tumor recurrence and metastasis(P0.01).Conclusion DOG-1 can be a potential reference marker for GIST diagnosis and prognosis.