Effects of continuous veno-venous hemofiltration on serum C-reactive protein level and APACHEII score in patients with multiple organ dysfunction syndrome

Objective To evaluate the effects of continuous veno-venous hemofiltration(CVVH) on serum C-reactive protein and APACHEⅡ score in patients with multiple organ dysfunction syndrome(MODS).Their clinical characteristics and the complications during CVVH were also observed.Methods Thirty-four patients with MODS,aged 19-91 years old,average age was(64±19) years,APACHEⅡscore was 24.6±3.4,were involved this study.The clinical conditions including blood pressures,heart rate,temperature,and respiratory condition were monitored every hour,also the liver function and renal function were monitor after the initiation of CVVH.The complications were investigated.Results Of 34 patients,25 patients survived through 14 days after CVVH(14-days survival rate 73.6%).Renal failure was presented in all patients before CVVH,and renal function all recovered after CVVH.Averaged age of survival patients was significantly lower than non-survival patients,and respiratory failure,coagulation disorder and heart failure in survival patients were also lower than in non-survival patients.CVVH was well tolerated in all of patients,who were maintained in a steady state of blood pressure and heart rate during CVVH.The APACH II score was decreased during CVVH in survival patients.The complications were bleeding in 8 cases all because of primary coagulation disorder.Conclusion CVVH therapy can get a survive rate of 29.4% and 14-days survive rate of 73.6% in patients with MODS,which was well tolerated because of low complication rate.The APACHEⅡscore and CRP level declined after CVVH,which may help to predict the outcome of patients with MODS.