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Mechanism and Effect of Compound Geshanxiao Granules on Gastrointestinal Motility

Lianjun Guo

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Abstract

Objective:To discuss mechanism and effect of Compound Geshanxiao granules on gastrointestinal motility.Method: Mouse intestinal propulsive activity was inhibited by atropine to observe the movement of small intestine.The rat functional dyspepsia model was established by clipping tail stimulation.The contents of nitrogen monoxidum(NO) in gastric mucous membrane,the level of rat blood gastrin(GAS) and motilin(MTL) were measured.Result: Compound Geshanxiao granules could apparently increase intestinal propulsive activity in mice,and decrease the contents of NO in gastric mucous membrane,meanwhile increase the contents of GAS in serum and MTL in plasma of functional dyspepsia model in rats.Conclusion: Compound Geshanxiao granules can improve intestinal propulsive activity,the mechanism may be related to decreasing the contents of NO in gastric mucous membrane and elevating the level of rat GAS in serum and MTL in plasma.

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What this paper is about

Objective:To discuss mechanism and effect of Compound Geshanxiao granules on gastrointestinal motility.Method: Mouse intestinal propulsive activity was inhibited by atropine to observe the movement of small intestine.The rat functional dyspepsia model was established by clipping tail stimulation.The contents of nitrogen monoxidum(NO) in gastric mucous membrane,the level of rat blood gastrin(GAS) and motilin(MTL) were measured.Result: Compound Geshanxiao granules could apparently increase intestinal propulsive activity in mice,and decrease the contents of NO in gastric mucous membrane,meanwhile increase the contents of GAS in serum and MTL in plasma of functional dyspepsia model in rats.Conclusion: Compound Geshanxiao granules can improve intestinal propulsive activity,the mechanism may be related to decreasing the contents of NO in gastric mucous membrane and elevating the level of rat GAS in serum and MTL in plasma.

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Available abstract

Objective:To discuss mechanism and effect of Compound Geshanxiao granules on gastrointestinal motility.Method: Mouse intestinal propulsive activity was inhibited by atropine to observe the movement of small intestine.The rat functional dyspepsia model was established by clipping tail stimulation.The contents of nitrogen monoxidum(NO) in gastric mucous membrane,the level of rat blood gastrin(GAS) and motilin(MTL) were measured.Result: Compound Geshanxiao granules could apparently increase intestinal propulsive activity in mice,and decrease the contents of NO in gastric mucous membrane,meanwhile increase the contents of GAS in serum and MTL in plasma of functional dyspepsia model in rats.Conclusion: Compound Geshanxiao granules can improve intestinal propulsive activity,the mechanism may be related to decreasing the contents of NO in gastric mucous membrane and elevating the level of rat GAS in serum and MTL in plasma.

Key concepts: Motilin, Motility, Atropine, Internal medicine, Chemistry, Mechanism (biology), Gastrin, Gastrointestinal hormone

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Mechanism and Effect of Compound Geshanxiao Granules on Gastrointestinal Motility — Research Paper | ScholarLens