Relationship between Urine Albumin and Vascular Endothelial Growth Factor in Children with Henoch-Schonlein Purpura

Objective To explore the correlation of urine albumin and vascular endothelial growth factor(VEGF) in the occurrence and progress of Henoch-Schonlein purpura(HSP) and HSP purpura nephritis(HSPN) in children.Methods There were 21 cases in control group and 29 children with HSP in experimental group.Urine albumin excretion rate(UAER) was measured by salicylic acid nephelometry,and the level of serum VEGF was measured by enzyme linked immunosorbent assay.The 29 cases with HSP were divided into HSP group (without renal injury) and HSPN group.The difference of UAER and VEGF in HSP or HSPN,and in HSPN before and after treatment were compared.Results Urine albumin of 24 hours had no difference between experimental group with HSP compared with and control group[(0.05±0.02) g/d vs (0.04±0.02) g/d P0.05],but significant difference existed in children with HSPN compared with HSP and control group[(3.01±1.52) g/d vs (0.05±0.02) g/d or (0.04±0.02) g/d Pa0.01].The level of serum VEGF had significant difference in children with HSP compared with control group[(98.2±48.3) ng/L vs (69.5±19.1) ng/L P0.05].VEGF had significant difference in children with HSPN compared with control group or children with HSP[(179.2±69.3) ng/L vs (69.5±19.1) ng/L or (98.2±48.3) ng/L Pa0.01].The level of urine albumin of 24 hours and VEGF were decreased obviously after treatment and had signi-ficant difference[(0.53±0.31) g/d vs (3.01±1.52) g/d,(81.4±59.6) ng/L vs (179.2±69.3) ng/L Pa0.01].The level of urine albumin of 24 hours had positive relationship with VEGF(r=0.519 P0.05).Conclusion VEGF participates in the formation of HSP and HSPN,and is related to occurence and progress of urine albumin.