Correlation of plasma vascular endothelial growth factor,urine microalbumin and β_2-microglobulin with early renal injury in children with Henoch-Schenlein purpura

Objective To explore the correlation of plasma vascular endothelial growth factor(VEGF),urine microalbumin(MA) and β2-microglobulin(β2-MG)with early renal injury in children with Henoch-Schenlein purpura(HSP).Methods Seventy-three cases of HSP were divided into skin type group(23 cases),mixed pattern group(28 cases) and Henoch-Schonlein purpura nephritis(HSPN) group(22 cases).Twenty-three of control group were healthy children.Twenty-five cases of post-treatment group had negative symptoms,normal urine analysis result and 24 h urine protein after 2 weeks treatment.Plasma VEGF was detected with enzyme-linked immunosorbent assay,Urine MA and β2-MG were detected with radioimmunoassay.Results The levels of plasma VEGF,urine MA and β2-MG in HSPN group were higher than these in skin type group and mixed pattern group(P0.05,P0.01),and these in post-treatment group were higher than these in control group(P0.05).It was positive correlation between VEGF and MA(r=0.444,P0.05),it was positive correlation between VEGF and β2-MG(r=0.275,P0.05).Conclusion VEGF,MA and β2-MG may involve in the development of HSPN,they were sensitive marker of renal damage in early stage of HSP patients.