The effects of temperature control treatment on 44 patients with large area cerebral infarction

Objectives To observe the effect of the decrease of body temperature gently for 72 hours on the improved value of neurologic impairment function.Methods 44 patients with large area cerebral infarction in Department of Neurology of the First Affiliated Hospital of Jinzhou Medical College from August 2004 to august 2005.They were divided randomly into 22 cases in treatment group with 12 males and 10 females,aged from 52 ～ 76 years old;22 cases in control group with 13 males and 9 females,aged from 48 ～ 75 years old.All the patients in the two groups were treated with routine drugs,and given reasonable sports rehabilitation according to disability situation.The icy bag and icy cap was put on patients,head and armpit added with alcohol Scoured and paracetamol which was put by nasal feeding in necessary in treatment group to maintain lower temperature.Results 44 patients were involved in the result analysis.①The improved value of neurologic impairment:It was significantly higher in treatment group than that in control group one week after treatment(P 0.01).It was also significantly higher in treatment group than that in control group 30 days after treatment(P 0.01).②The score of Barthel index:It was higher in treatment group than that in control group one week after treatment.(P 0.01).It was also significantly higher in treatment group than that in control group one week after treatment.(P 0.01).When entered the group,after 1 week and after 30 days all the patients were performed respectively by MESS,and the highest mark was 45 points and the lowest mark was 0 point.The higher the mark,the more serious the defection;the activities of daily living was evaluated by Barthel index,including 10 contents,and the highest mark was 100 points and the lowest mark that was the most severity was 0 point.③The comparison of temperature between the two groups:It was lower in treatment group than that in control group one week after treatment(P 0.05).It was also significantly lower in treatment group than that in control group 30 days after treatment(P 0.01).Conclusions The results show that early gently hypothermia can significantly ameliorate the level of neurologic impairment,improve the ability of activities of daily living.