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Clinical Distrubution and Drug Resistance of 397 Strains of Pseudomonas aeruginosa

Liu XingChao, Zeng GuiFen, Fei YanNan, Songlin Hu

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Abstract

OBJECTIVE To study the clinical distrubution and drug resistance of Pseudomonas aeruginosa and guide drug treatment in clinic.METHODS P.aeruginosa was indentified by ATB Expression system,and its antimicrobial resistance was determined by Kirby-Bauer method.RESULTS A total of 397 strains of P.aeruginosa was isolated,and 74.1% of them were isolated from respiratory tract specimens which were sent from Department of Cadre,Department of Neurosurgery and Department of Burn.The P.arruginosa were more susceptible to ceftazidime,amikacin,piperacillin/tazobactam and cefoperazone/sulbactam with the rates of 71.5%,67.2%,63.0% and 64.2%,respectively.The resistance rate to imipenem was 41.8%.CONCLUSION P.aeruginosa is one of the main pathogenic bacteria to cause nosocomial infection.And most of them show severe drug resistance to antibiotics,and the resistant rate to carbapenem is high.

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OBJECTIVE To study the clinical distrubution and drug resistance of Pseudomonas aeruginosa and guide drug treatment in clinic.METHODS P.aeruginosa was indentified by ATB Expression system,and its antimicrobial resistance was determined by Kirby-Bauer method.RESULTS A total of 397 strains of P.aeruginosa was isolated,and 74.1% of them were isolated from respiratory tract specimens which were sent from Department of Cadre,Department of Neurosurgery and Department of Burn.The P.arruginosa were more susceptible to ceftazidime,amikacin,piperacillin/tazobactam and cefoperazone/sulbactam with the rates of 71.5%,67.2%,63.0% and 64.2%,respectively.The resistance rate to imipenem was 41.8%.CONCLUSION P.aeruginosa is one of the main pathogenic bacteria to cause nosocomial infection.And most of them show severe drug resistance to antibiotics,and the resistant rate to carbapenem is high.

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Available abstract

OBJECTIVE To study the clinical distrubution and drug resistance of Pseudomonas aeruginosa and guide drug treatment in clinic.METHODS P.aeruginosa was indentified by ATB Expression system,and its antimicrobial resistance was determined by Kirby-Bauer method.RESULTS A total of 397 strains of P.aeruginosa was isolated,and 74.1% of them were isolated from respiratory tract specimens which were sent from Department of Cadre,Department of Neurosurgery and Department of Burn.The P.arruginosa were more susceptible to ceftazidime,amikacin,piperacillin/tazobactam and cefoperazone/sulbactam with the rates of 71.5%,67.2%,63.0% and 64.2%,respectively.The resistance rate to imipenem was 41.8%.CONCLUSION P.aeruginosa is one of the main pathogenic bacteria to cause nosocomial infection.And most of them show severe drug resistance to antibiotics,and the resistant rate to carbapenem is high.

Key concepts: Pseudomonas aeruginosa, Sulbactam, Cefoperazone, Piperacillin, Drug resistance, Imipenem, Amikacin, Microbiology

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