Expression of MDR, gene in hepatocelhllar cardnoma

To explore the expression and clinical significance of Pgp in hepatocellular carcinoma (HCC) and its surrounding liver tissues. The expression of Pgp in 78 cases of HCC and 60 surrounding normal liver tissues was detected with immunohistochemical SABC. The relationship between Pgp expression in HCC tissues and clinicopathological features of the tumors was also analyzed. The expression of Pgp mainly lied on the membrance of carcinoma and biliary duct cells and a few in plasma. Pgp positive rate in liver tissues was significantly higher than that in carcinoma tissues in untreated patients(56.4%VS26.0% ,U=2.65,P0.01). The positive rate of Pgp in tumor tissue after treatment was over 50% . The expression of Pgp in carcinoma tissues was only related to tumor cell differentiation ( x2= 5.87, P 0.05 ) . Liver is an intrinsic drug - resistance organ, and durg - resistance of HCC was enhanced after treatment. A reasonable chemotherapy protocol should be selected.