ScholarLens Back to search
2011•Dalian Yike Daxue xuebaoRequires access

Study of the effect of fluroquinolone combination on the mutant selection window(MSW) of Staphylococcus aureus

Chunfang Liu

Open publisher page 0 citations

Abstract

[Objective] To study the effect of fluroquinolone combination on the mutant selection window(MSW) of staphylococcus aureus in vitro.[Methods] MIC for 38 clinical isolates of staphylococcus aureus and quality control(ATCC25923) were determined by the standard two fold agar dilution methods.MPC of fluoroquinolones against strains were determined by agar dilution methods.The values of MPC50,MPC90 and MPC/MIC were calculated.SPSS statistics software was used to analyze the data.[Results] After combined with cephazoline,MPC90/MIC90 of levofloxacin was down from 16 to 8,that of moxifloxacin was also down from 4 to 1.[Conclusions] Combined with cephazoline,fluoroquinolone could narrow or even close the MSW which fluoroquinolone only produces,reduce the selective enrichment of resistant mutants,and prevent development of drug resistant.

About this research paper

What this paper is about

[Objective] To study the effect of fluroquinolone combination on the mutant selection window(MSW) of staphylococcus aureus in vitro.[Methods] MIC for 38 clinical isolates of staphylococcus aureus and quality control(ATCC25923) were determined by the standard two fold agar dilution methods.MPC of fluoroquinolones against strains were determined by agar dilution methods.The values of MPC50,MPC90 and MPC/MIC were calculated.SPSS statistics software was used to analyze the data.[Results] After combined with cephazoline,MPC90/MIC90 of levofloxacin was down from 16 to 8,that of moxifloxacin was also down from 4 to 1.[Conclusions] Combined with cephazoline,fluoroquinolone could narrow or even close the MSW which fluoroquinolone only produces,reduce the selective enrichment of resistant mutants,and prevent development of drug resistant.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

[Objective] To study the effect of fluroquinolone combination on the mutant selection window(MSW) of staphylococcus aureus in vitro.[Methods] MIC for 38 clinical isolates of staphylococcus aureus and quality control(ATCC25923) were determined by the standard two fold agar dilution methods.MPC of fluoroquinolones against strains were determined by agar dilution methods.The values of MPC50,MPC90 and MPC/MIC were calculated.SPSS statistics software was used to analyze the data.[Results] After combined with cephazoline,MPC90/MIC90 of levofloxacin was down from 16 to 8,that of moxifloxacin was also down from 4 to 1.[Conclusions] Combined with cephazoline,fluoroquinolone could narrow or even close the MSW which fluoroquinolone only produces,reduce the selective enrichment of resistant mutants,and prevent development of drug resistant.

Key concepts: Staphylococcus aureus, Agar Dilution Method, Microbiology, Moxifloxacin, Agar dilution, Agar, Mutant, Levofloxacin

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Study of the effect of fluroquinolone combination on the mutant selection window(MSW) of Staphylococcus aureus — Research Paper | ScholarLens