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2006•Zhongguo kangganran hualiao zazhiRequires access

Mutant prevention concentration of fluoroquinolones against ciprofloxacin-susceptible Staphylococcus aureus

Wang Yu-me

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Abstract

ObjectiveTo determine the mutant prevention concentration(MPC) of 4 fluoroquinolones against clinical isolates of ciprofloxacin-susceptible Staphylococcus aureus.MethodsMinimum inhibitory concentrations(MICs) and MPCs were determined by agar dilution against 20 isolates of ciprofloxacin-susceptible S.aureus.MPC_(90) and MPC_(90)/MIC_(90) were calculated.ResultsThe MPCs of gatifloxacin,pazufloxacin,levofloxacin and ciprofloxacin for S.aureus were 1.2,4.0, 4.0 and 8 mg/L respectively.The ratio of MPC_(90)/MIC_(90) of the 4 fluoroquinolones was 8,16,16 and 16 respectively.MIC values were not consistent with MPCs.A small fraction of strains tested survived for 96 h at MPC.But MIC values did not change.ConclusionsThe ability of gatifloxacin for restricting the selection of resistant mutant of S.aureus is stronger than that of pazufloxacin,levofloxacin and ciprofloxacin.MPC can not be predicted from MIC.

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ObjectiveTo determine the mutant prevention concentration(MPC) of 4 fluoroquinolones against clinical isolates of ciprofloxacin-susceptible Staphylococcus aureus.MethodsMinimum inhibitory concentrations(MICs) and MPCs were determined by agar dilution against 20 isolates of ciprofloxacin-susceptible S.aureus.MPC_(90) and MPC_(90)/MIC_(90) were calculated.ResultsThe MPCs of gatifloxacin,pazufloxacin,levofloxacin and ciprofloxacin for S.aureus were 1.2,4.0, 4.0 and 8 mg/L respectively.The ratio of MPC_(90)/MIC_(90) of the 4 fluoroquinolones was 8,16,16 and 16 respectively.MIC values were not consistent with MPCs.A small fraction of strains tested survived for 96 h at MPC.But MIC values did not change.ConclusionsThe ability of gatifloxacin for restricting the selection of resistant mutant of S.aureus is stronger than that of pazufloxacin,levofloxacin and ciprofloxacin.MPC can not be predicted from MIC.

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Available abstract

ObjectiveTo determine the mutant prevention concentration(MPC) of 4 fluoroquinolones against clinical isolates of ciprofloxacin-susceptible Staphylococcus aureus.MethodsMinimum inhibitory concentrations(MICs) and MPCs were determined by agar dilution against 20 isolates of ciprofloxacin-susceptible S.aureus.MPC_(90) and MPC_(90)/MIC_(90) were calculated.ResultsThe MPCs of gatifloxacin,pazufloxacin,levofloxacin and ciprofloxacin for S.aureus were 1.2,4.0, 4.0 and 8 mg/L respectively.The ratio of MPC_(90)/MIC_(90) of the 4 fluoroquinolones was 8,16,16 and 16 respectively.MIC values were not consistent with MPCs.A small fraction of strains tested survived for 96 h at MPC.But MIC values did not change.ConclusionsThe ability of gatifloxacin for restricting the selection of resistant mutant of S.aureus is stronger than that of pazufloxacin,levofloxacin and ciprofloxacin.MPC can not be predicted from MIC.

Key concepts: Gatifloxacin, Ciprofloxacin, Levofloxacin, Staphylococcus aureus, Microbiology, Minimum inhibitory concentration, Agar Dilution Method, Agar dilution

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