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2011•Zhongguo laonianxue zazhiRequires access

Effect of edaravone-administration on GSK-3β in substantia nigra of Parkinson′s disease mice model

Wen Wang

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Abstract

Objective To investigate the protective effect of edaravone on nigrostriatal dopaminergic neurons in Parkinson′s disease(PD) mice induced by paraquat and maneb.Methods Male C57BL/6 mices were randomly divided into paraquat(PQ) + maneb(MN) treated,edaravone treated and control groups.Behavioral and immunohistochemical changes were to detect the motor coordination and the expression of tyrosine hydroxylase(TH) and GSK-3β in the substantia nigra pars compacta(SNc).Results Edaravone significantly attenuated the impairment of behavioral performance,increased the number of TH positive neurons and decreased the expression of GSK-3β in SNc.Conclusions Edaravone has a beneficial influence on PD induced by PQ+MB.

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What this paper is about

Objective To investigate the protective effect of edaravone on nigrostriatal dopaminergic neurons in Parkinson′s disease(PD) mice induced by paraquat and maneb.Methods Male C57BL/6 mices were randomly divided into paraquat(PQ) + maneb(MN) treated,edaravone treated and control groups.Behavioral and immunohistochemical changes were to detect the motor coordination and the expression of tyrosine hydroxylase(TH) and GSK-3β in the substantia nigra pars compacta(SNc).Results Edaravone significantly attenuated the impairment of behavioral performance,increased the number of TH positive neurons and decreased the expression of GSK-3β in SNc.Conclusions Edaravone has a beneficial influence on PD induced by PQ+MB.

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Available abstract

Objective To investigate the protective effect of edaravone on nigrostriatal dopaminergic neurons in Parkinson′s disease(PD) mice induced by paraquat and maneb.Methods Male C57BL/6 mices were randomly divided into paraquat(PQ) + maneb(MN) treated,edaravone treated and control groups.Behavioral and immunohistochemical changes were to detect the motor coordination and the expression of tyrosine hydroxylase(TH) and GSK-3β in the substantia nigra pars compacta(SNc).Results Edaravone significantly attenuated the impairment of behavioral performance,increased the number of TH positive neurons and decreased the expression of GSK-3β in SNc.Conclusions Edaravone has a beneficial influence on PD induced by PQ+MB.

Key concepts: Substantia nigra, Edaravone, Pars compacta, Maneb, Paraquat, Tyrosine hydroxylase, Parkinson's disease, Dopaminergic

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Effect of edaravone-administration on GSK-3β in substantia nigra of Parkinson′s disease mice model — Research Paper | ScholarLens