Clinical significance of the changes of plasma adiponectin levels in patients with coronary artery disease

Objective:To observe the plasma adiponectin leves in patients with coronary artery disease(CAD) and evaluate the relationship between adiponectin and the development of acute coronary syndrome(ACS).Method:A total of 110 CAD patients conformed by coronary angiography were divided into stable angina pectoris (SAP)(n=35),unstable angina pectoris(UAP)(n=42) and acute myocardial infartion (AMI)group (n=33),while 20 healthy adults were selected as control group. Plasma adiponectin levels were measured by ELISA,and others by routine method. Rusult:Plasma adiponectin levels in patients with AMI or UAP were significantly lower than in patients with SAP and control. Multiple logistic regression analysis showed that smoking,fasting blood glucose,and low plasma adiponectin concentrations correlated independently with the development of ACS. Conclusion:Measurement of plasma adiponection may be used for assessing the risk of CAD and may be related to the development of ACS.