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Effect of Angelicasinensis Injection on Myocardial Hypertrophy Induced by AngiotensinII

Di M

Abstract

Objective: To observe the effect of Angelicasinensic (DangGui) injection on hypertrophic cardiomyocyte through establishing model of my-ocardical hypertrophy. Methods: Neonatal rat ventricular myocytes were isolated and cultured in vitro. Myocardical hypertrophy was induced by An-giotensin Ⅱ (Ang Ⅱ ). Then access the effect of Angelicasinensic (DangGui) injection on the myocardical hypertrophy by the following method: Measure diameter of myocytes and content of cellular protein. Results: Ang Ⅱ can obviously increase the diameter of myocytes and the cellular protein content of myocytes (P0.01) while Angelicasinensic (DangGui) injection can decrease the improvement in the cellular diameter and protein con-tent(P0.05). Conclusion: Angiotensin Ⅱ (Ang Ⅱ ) has the effect of inducing hypertrophy and Angelicasinensic (DangGui) injection can inhibit myocardial hypertrophy certainly.

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Key concepts: Muscle hypertrophy, Myocardial hypertrophy, Myocyte, Internal medicine, Medicine, Cardiology, In vitro, Cardiac hypertrophy