2009•Zhongguo linchuang yixueRequires access

The Effect of TSNIIA on Myocardial Hypertrophy Induced by AngiotensionII

Bo Wen

Abstract

Objective:To explore the depressant effect of TSNⅡA( Tanshinone ⅡA) on myocardial hypertrophy induced by angiotensin Ⅱ(Ang Ⅱ) in cultured neonatal Wistar rat myocardical cells.Methods:The cultured neonatal rat cardiomyocytes were treated with AngⅡ(10-6mol·L-1),TSNⅡA(10-8mol·L-1),and AngⅡ(10-6mol·L-1)+ TSNⅡA(10-8mol·L-1) respectively in free-serum medium for 36 h. The cell size,3H-Leucine incorporation and total protein level were investigated.Results:TSNⅡA could antagonize the AngⅡ induced increas the cell size,3H-Leucine incorporation and total protein level.Conclusions:TSNⅡA prevens cardiomyocytes from hypertrophy induced by AngⅡ.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Medicine, Muscle hypertrophy, Myocardial hypertrophy, Cardiac hypertrophy, Internal medicine, Endocrinology, Leucine, Angiotensin II