Comparative study on elderly schizophrenics by aripiprazole and risperidone

Objective To compare the efficacy,quality of life and safety of aripiprazole to treat elderly schizophrenics. Methods 80 elderly schizophrenic patients were randomly divided into aripiprazole group and risperidonegroup for 12 weeks. The efficacy was measured with Positive and Negative Syndrome Scale for schizophrenia ( PANSS) ,the side effects were assessed by the treatment emergent symptom scale ( TESS) ,the WHO Quality of Life-100 scale( WHQOL-100) for quality of life. Results By the end of the 12 weeks,the scores of PANSS and WHQOL-100 in two groups changed notably ( P 0. 01) 。There was no significant difference between the two groups ( P 0. 05) 。The occurrence rate of extrayramidal side effects,tachycardia and increased weight in the aripiprazole group was significantly lower than in the rispridone group ( P 0. 01). Conclusion The results suggest that aripiprazole is effective,safety and good compliance for the treatment of elderly schizophrenics,It can improve the patients,quality of life efficiently,Aripiprazole is beneficial for elderly schizophreni-a.