Effect of Endoscopic Hemoclips and Omeprazole on Patients With Active Bleeding Peptic Ulcer

Objective: To evaluate the efficacy of endoscopic hemoclips combined with intravenous omeprazole for bleeding peptic ulcer in comparison with omeprazol only. Methods: Seventy-five peptic ulcer patients with active bleeding were randomly divided into two groups. In the treatment group, the patients were treated with endoscopic hemoclips and omeprazole. In the control group, the patients only received omeprazole. Results: The hemostatic rate was 94.11% in the treatment group, and was 73.17% in the control group with significant difference (χ~ 2= 5.69, P 0.05). Re-bleeding occurred in 2 patients( 5.9%)in the treatment group, and 11 patients( 26.8%)in treatment the control group(P 0.05).The mean volume of blood transfusion was 3.1± 2.0 u (1 u=200 ml) in the group, and 2.2± 1.9 u in the control group(P 0.05). There was significant difference in time required for hemostasis between two groups(P 0.05). Conclusion: Endoscopic hemoclips combined with omeprazole can effectively reduce re-bleeding rate, time required for hemostasis and increase hemostatic rate in patients with bleeding peptic ulcer. It is recommended in the treatment for patient with bleeding peptic ulcer.