2006•The Chinese Journal of Modern Applied PharmacyRequires access
Study on the preparation of Iorhoxicam injection——Solubilization of lornoxicam
Yuan Gao, Jianjun Zhang, Weiming Fan, Ren Bing-jun
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Abstract
OBJECTIVE To study the solubility of lornoxicam,a waterinsoluble non-steroidal anti-inflammatory drug,for the purpose of the preparation of its parenteral injection.METHODS Solubility determination was performed by HPLC method.The effect of pH control,cosolvency,micellization and HPβCD complexation was investigated for the preformulation of lornoxicam aqueous injection. RESULTS The solubility of lornoxicam(S_(T)) increased exponentially with the elevation of pH value and linearly with the concentration of three surfactants and HPβCD.Linear correlation also existed between the logarithm of S_(T)and solvent fraction of three cosolvents(r0.98).CONCLUSION The effect of commonly used injectable surfactants and cosolvents on the solubility of lornoxicam is not marked.The solubility of lornoxicam can be significantly enhanced to achieve the requirement of lornoxicam injection formulation by pH control and HPβCD complexation.