The Solubilization Effect of 2-hydroxypropy1-β-cyclodextrin on Lornoxicam

Aim To study the solubilization effect of 2-hydroxypropy1-β-cyclodextrin,(HPCD) of various pH and concentrations on lornoxicam.[Methods The solubization experiment was done by the phase-solubility method,and the concentration of lornoxicam was determined by the UV method.The stability constants(K) of the conclusion complex could be calculated from the regression equation:K=slope/intercept(1-slope).Results The solubility of lornoxicam was enhanced rapidly with the increase of HPCD concentration and increase of pH.The solubilization effect on lornoxicam is 0.499,1.791,2.405mg·ml -1 at pH7,pH8,pH9.The stability constants were calculated at various pH.The stability constants(K) were 132.42,66.53,38.60 at pH7,pH8,pH9.T5HZ]Conclusion Lornoxicam-HP-CD conclusion complex could be formed,HPCD is a desirable solubilizer for lornoxicam.