The relevant research between hypertension variability and renal dysfunction in primary high blood pressure patients

Objective:To evaluate the association between blood pressure variability and renal function injury in the patients with essential hypertension. Methods:86 cases of patients with mild to moderate essential hypertension were divided into EH1 group (43 cases) and EH2 group (43 cases) based on the mean variability of 24 h systolic blood pressure in ascending order. 24 h ambulatory blood pressure,quantitative of 24 h urine microalbumin and renal function determination were recorded. Results:The blood pressure variability of two groups has a significant difference (P0.01),mean SBP and DBP of 24 h,daytime,night-time were no statistical significance (P0.05),the quantitative of 24 h urine microalbumin of two groups were significant difference (P0.01),the SBP and DBP blood pressure variability were positive correlation with 24 h urine microalbumin except the daytime blood pressure variability. Serum creatine (Scr) and serum BUN of two groups were no significant difference(P0.05). Conclusion:Blood pressure variability is closely related with hypertensive renal injury in the patients with essential hypertension.